Injection grade Oral grade Daily chemical grade Technical grade Hydroxypropyl betadex HPBCD/HP-β-CD CAS 128446-35-5

Short Description:


  • Min.Order Quantity: Up to request
  • Port: Main Port of China
  • Payment Terms: L/C,D/A,D/P,T/T,WU,PAYPAL,TRADE ASSURANCE
  • Packing: Drum, IBC, BAG or As Per Request
  • Cas no.: 128446-35-5
  • Product Detail

    Product Tags

    Hydroxypropyl betadex

    Cas no.

    128446-35-5

    abbreviation

    HPBCD, HP-β-CD

    English name

    Hydroxypropyl betadex

    Hydroxypropyl-β-cyclodextrin

    Hydroxypropyl-beta-cyclodextrin

    Molecular formula

    C42H70-nO35(C3H7O)n

    HPBCD

    Product features

    Hydroxypropyl betadex (HP-β-CD) is a hydroxyalkylated derivative of beta cyclodextrin (B-CD). Hydroxypropyl betadex is non-toxic and has no side effects. Because of its special structure, it can greatly improve the solubility of insoluble drugs and make insoluble or insoluble drugs soluble in water. Therefore, it can effectively improve the bioavailability of drugs, greatly improve the drug quality and dosage forms, and is widely used in the development and production of new drugs.

    main functions

    Solubilization and solubilization, anti-oxidation, odor, slow release, targeted drug delivery, etc.

    Product qualification

    CDE platform – drug excipient registration number

    Hydroxypropyl betadex (Oral): F20209990366 (Transferred “A”)

    Hydroxypropyl betadex (injection): F20180001469

    USA DMF Registration No.

    Hydroxypropyl betadex DMF NO.: 030168

    Product Category

    Injection grade: The product has the characteristics of ultra-low beta cyclodextrin residues, and is used for solubilization and solubilization of injection drugs.

    Oral grade: The product has the characteristics of solubilization, anti-oxidation, odor, slow release, targeted drug delivery, etc.

    Daily chemical grade: It can reduce the irritation of organic molecules in cosmetics to skin and mucous membrane.

    Technical grade: It is mainly used in industrial fields, such as coatings, sterol pigments, pumping activators, etc.

    40% Hydroxypropyl betadex aqueous solution: Enterprise standard, lower cost.

    Product performance

    [Medical field]

    Hydroxypropyl betadex is an ideal solubilizer and excipient for injection.

    (1) Solubilization and solubilization, dissolve insoluble drugs, improve the solubility of effective components of oily drugs, target drug delivery and protect the effectiveness of drug components.

    (2) Improve the bioavailability of the drug, so as to increase the efficacy of the drug or reduce the dosage.

    (3) Adjust or control the release rate of drugs to reduce their toxic and side effects.

    (4) Cover up the bad smell.

    [Scope of application]

    It can be used for oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, lipophilic targeted drug carriers, as well as protein protectants and stabilizers.

    [Daily chemical field]

    It can be used as stabilizer, emulsifier, flavor agent, etc. in cosmetics raw materials to reduce the irritation of organic molecules in cosmetics to skin and mucous membrane, enhance the stability of effective ingredients, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity. Cyclodextrin can also be used as emulsifier and quality improver in cosmetics manufacturing. It also has deodorization (such as deodorization) and antiseptic effects, and can be used in the manufacture of toothpaste and tooth powder.

    [Industrial field]

    Due to the special molecular structure of Hydroxypropyl betadex, the application field of this product has been expanding. In addition to drug use, it has been widely used in textile, gas purification, environmental protection, pesticides, flavors and fragrances, toothpaste and toothbrushes, and other chemical fields. We has developed Hydroxypropyl betadex products with different quality requirements according to the use characteristics.

    [Food flavor field]

    Hydroxypropyl betadex can improve the stability and long-term effectiveness of nutrient molecules, cover up or correct the bad smell and taste of food nutrient molecules, improve the production process and product quality, and increase the shelf life of products. The solubility of the product in water is very good. The substitution degree 4 and above can be mixed with water in any proportion, and it can also be dissolved in 50% ethanol and methanol.

    [chromatographic analysis]

    Hydroxypropyl betadex can be used as stationary phase and mobile phase in chromatographic analysis.

    A new method of preparing cyclodextrin for chromatographic phase determination is to first bond cyclodextrin to silica gel, and then derivate cyclodextrin hydroxyl, such as methylation, acetylation, hydroxypropylation, etc., to improve the performance of the stationary phase and achieve better separation effect. Hydroxypropyl betadex added to the mobile phase can selectively change the interaction between the components to be separated and the stationary phase to improve the separation effect.

    Product advantages

    (1) Quality standards of various specifications: injection grade, pharmaceutical oral grade, daily chemical grade and technical grade for your choice.

    (2) The quality is guaranteed, and has been audited by domestic and foreign customers for many times and has been praised.

    (3) Complete qualification, obtaining the “approval document for the production of pharmaceutical excipients”, obtaining the DMF record No.: 030168

    (4) Strong supply capacity, with a capacity of 1000 tons/year.

    (5) Professional domestic and foreign trade personnel, familiar with the operation process.

    (6) We have a long-term cooperation in professional logistics and express delivery to ensure safe transportation and timely delivery.

    (7) Provide technical support.

    Manufacturer advantages

    (1) The manufacturer has a high standard GMP workshop. Strong supply capacity, reliable quality, advanced technology and stable products.

    (2) The manufacturer has complete production and inspection facilities and has successfully passed the audit of many domestic and foreign pharmaceutical enterprises. People oriented, continuously improve the quality level, and fully meet customer requirements. At present, it has passed ISO9001 quality system certification, ISO14001:2015 environmental management system certification, and IS045001:201 8 occupational health and safety management system certification, thus standardizing the whole process of cyclodextrin production. There are standard processes for product quality from raw material procurement, inspection to the entire production process and warehousing. The product standards comply with USP/EP/CP/enterprise standards. The manufacturer operates in strict accordance with IS09001: 9001 quality system. Conduct quality management and supervision for each production link. Each process of our production is carried out in strict accordance with the procedures specified in our quality manual, and quality problem analysis meetings are held regularly to solve the quality problems encountered in the production process. Strive to provide each customer with qualified products of internal quality.

    (3) Technical advantages: The manufacturer has established a high standard R&D laboratory, a quality control laboratory, a microbiological laboratory and a synthesis laboratory, and has established a cyclodextrin application R&D center with universities. Manufacturers continue to increase investment in scientific research and technology, strengthen the construction of manufacturers’ R&D strength, expand the R&D team, purchase advanced R&D testing equipment, improve the overall technical strength of manufacturers, and provide a solid guarantee for the stability of product quality.

    Packing

    (1) Packaging: sterile PE bag, aluminum foil bag

    (2) Outer package: fiber drum, carton

    (3) Package specification:

    Injection grade/oral grade/daily chemical grade: 10kg/drum, 20kg/drum

    Technical grade: 15kg/box, 16.33kg/box (carton)

    Oral Grade

    Injection Grade

    Package size (cm)

    37*37*48

    37*37*55

    CBM (m3)

    0.066

    0.075

    N.W.(KGS)

    10kg/fiber drum

    20kg/fiber drum

    G.W.(KGS)

    12.5kg/fiber drum

    22.9kg/fiber drum

    Pallet Size

    120*120*15

    120*120*15

    Pallet N.W.(KGS)

    20kgs

    20kgs

    QTY

    9 fiber drums/layer total 18 fiber drums/pallet

    9 fiber drums/layer total 18 fiber drums/pallet

    Storage conditions

    Storage conditions: sealed and stored at room temperature

    Validity: 2 years

    Product specifications

    Contact us for product inspection specifications.

    Contacts: Bruce Mu/Bruce_mu@labeyond.com


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